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Copyright © 2015 BIF Centre, University of Kalyani.
Developed & Maintained by
BIF Centre,
Department of Biochemistry & Biophysics,
University of Kalyani, Kalyani,
Nadia-741 235,
West Bengal India.
Semanti Ghosh.
University research Scholar (URS-SRF)
M.Sc. In Molecular Biology & Biotechnology
e-mail ID: semanti2007@gmail.com

Subject Area:
Computational Biology, Protein-protein interaction, Protein-Ligand interaction, Protein-DNA interaction, Molecular Docking, Homology Modeling, Machine Learning, Drug Designing, Molecular Simulation, Membrane simulation.
Research Area- In silico study of sulfur metabolism
Sulfur metabolism is one of the oldest known proceesses mediated by diverse sets of microorganisms. Different types of sulfur metabolism involves assimilatory and dissimilatory pathaways. During the metabolism sulfide and thiosulfate are first oxidized to elemental sulfur. Then the sulfur is further oxidized to sulfate via sulfite. One of the players of sulfur metabolism is the dsr (dissimilatory sulfite reductase) operon. The proteins encoded by the dsr operon are essential for the transfer of sulfur globules from periplasm to cytosol and oxidation of the stored sulfur by dissimilatory sulfite reductase enzyme present in cytoplasm. The electrons released by sulfite reductase are fed into photosynthetic electron flow via the membrane complex to HiPIP, the primary electron donor to the photosynthetic reaction center.  The basic architecture of the dsr operon is nearly the same for all the different organisms. In the present work we are concentrating on the organism Allochramatium vinosum (A. vinosum) because of its involvements in different biotechnological applications like waste remediation and removal of toxic compounds, e.g. odorous sulfur compounds like sulfide or even explosives. The organism is used also in the production of industrially relevant organo-chemicals such as vitamins or bio-polyesters and the production of biohydrogen. The dsr operon of A. vinosum consists of 15 genes dsrABEFHCMKLJOPNRS. In the present work I tried to cover almost every aspect of dsr operon in the sulfur metabolism. Our work would be beneficial as a first hand guide to the researchers interested in sulfur biochemistry.


Research Publications:


2013:

1. Mutation study of DsrM from Allochromatium vinosum using the amino acid sequences
Semanti Ghosh and Angshuman Bagchi. Meta Gene 1 (2013) p.33-42. Published by Elsevier 

2. Characterization of DsrK and DsrO from Allochromatium vinosum and other Proteobacteria Using the Amino Acid Sequences. 
Semanti Ghosh and Angshuman Bagchi. Research and Reviews: Journal of Material Sciences. e-ISSN:2321-6212. p-ISSN:2347-
2278. October-December, 2013. Pp 31-38.

3. Amino Acid Sequence Comparison of DsrP Protein from Proteobacteria to Analyze the Probable Molecular Mechanism of 
Sulfur Oxidation Process <http://benthamopen.com/ABSTRACT/TOSBJ-5-1>
The Open Structural Biology Journal <http://benthamopen.com/TOSBJ/home/>, ISSN: 1874-1991 2013, 5: 1-10
Semanti Ghosh, Angshuman Bagchi Electronic publication date 29/11/2013
[DOI: 10.2174/1874199101305010001 <http://dx.doi.org/10.2174/1874199101305010001>]

2014:


1. Hypoglycosylation of dystroglycan due to T192M mutation: A molecular insight behind the   fact. Simanti Bhattacharya, Amit Das, 
Semanti Ghosh, Rakhi DasGupta, Angshuman Bagchi. Gene. 537 (1) (March 2014) 108-114, ISSN: 0378-1119.

2. Book Chapter: 


Analysis of the Structural Details of DsrO Protein from Allochromatium vinosum to Identify the Role of the Protein in the 
Redox Transport Process Through the dsrOperon Semanti Ghosh and Angshuman Bagchi
Springer Briefs in Applied Sciences and Technology; Forensic and Medical Bioinformatics
Series editors: Amit Kumar, Hyderabad, India and Allam Appa Rao, Hyderabad, India. Naresh Babu Muppalaneni and Vinit Kumar 
Gunjan Editors of Computational Intelligence in Medical Informatics ISSN 2191-530X ISSN 2191-5318 (electronic) ISBN 978-
981-287-259-3 ISBN 978-981-287-260-9 (eBook) DOI 10.1007/978-981-287-260-9. Pp 1-10. 

2015:

1. Comparative analysis of the mechanisms of sulfur anion oxidation and reduction by dsr operon, Semanti Ghosh and Angshuman 
Bagchi. Computational Biology and Chemistry 59 (2015) 177-184.http://dx.doi.org/10.1016/j.compbiolchem.2015.07.001.

Book Chapter:

Intermolecular Interaction Study Of Dissimilatory Sulfite Reductase (DsrAB) from Sulfur Oxidizing Proteobacteria Allochromatium 
vinosum Semanti Ghosh and Angshuman Bagchi
Information Systems Design and Intelligent Applications
Proceedings of Second International Conference INDIA 2015, Volume 2
Series: Advances in Intelligent Systems and Computing, Vol. 340
Mandal, J.K., Satapathy, S.C., Kumar Sanyal, M., Sarkar, P.P., Mukhopadhyay, A. (Eds.)
ISBN 978-81-322-2247-7
University of Kalyani, Nadia, West-Bengal, India.
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