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Copyright © 2015 BIF Centre, University of Kalyani.
Developed & Maintained by
BIF Centre,
Department of Biochemistry & Biophysics,
University of Kalyani, Kalyani,
Nadia-741 235,
West Bengal India.
Snachari Bhattacharjee.
Junior Research Fellow
M.Sc. in Zoology
E mail ID: sancharib88@gmail.com


Subject Area:

Computational Biology, Protein-protein interaction, Protein-Ligand interaction, Molecular Docking, Homology Modeling, Molecular Simulation.

Research Area:  in-silico study of molecular mechanism of small heat-shock proteins IbpA and IbpB in Escherichia coli
Cells live in diverse environments and so face different kinds of stresses which include temperature stress, pH stress, superoxide stress, toxin stress etc. These cellular stresses impose a challenge to its survival and normal machinery of the cell. Heat stress or heat shock may result in formation of disaggregated structure, misfolded as well as damaged proteins which make a burden to the living cells. Inclusion body protein A (IbpA) and Inclusion body protein B (IbpB) are small heat shock proteins of Escherichia coli, are two highly conserved proteins show increased expression and activity during temperature elevation. These proteins oligomerise with each other and recognize heat stressed misfolded proteins through their terminal regions to restore the intermediate folding competent state of the aggregated proteins by eliciting its heat-shock response. Once the intermediate state is achieved, they send this stressed protein to Foldase proteins to initiate proper folding. As IbpA and IbpB do not have a foldase activity and can only prevent the cellular heat-stressed proteins from being misfolded, so they act as holdase heat-shock proteins. These proteins act efficiently at stressed temperature. In my research work I tried to cover almost every aspect of molecular mechanistic details of IbpA and IbpB interactions. Our work would be beneficial to the researchers interested in cellular stress and heat-shock response mechanism of small heat-shock proteins.




List of Publications:

1.Bhattacharjee S, Bagchi A and Dasgupta R; Structural Bioinformatic Approach to Understand the Molecular Mechanism of the Interactions of small heat shock proteins IbpA and IbpB with Lon Protease published in the book Advances in Intelligent System and Computing. Proceedings of Second International Conference INDIA 2015, Volume 2, Series: Advances in Intelligent Systems and Computing, Vol. 340. Mandal, J.K., Satapathy, S.C., Kumar Sanyal, M., Sarkar, P.P., Mukhopadhyay, A. (Eds.) ISBN 978-81-322-2247-7
2.Bhattacharjee S, Dasgupta R, Bagchi A; Structural insights into IbpA-IbpB interactions to Predict their roles in heat shock response; Computational Intelligence in Medical Informatics (2015) Springer Briefs in Applied Sciences and Technology; Forensic and Medical Bioinformatics ,Series editors: Amit Kumar, Hyderabad, India and Allam Appa Rao, Hyderabad, India. Naresh Babu Muppalaneni and Vinit Kumar Gunjan Editors of Computational Intelligence in Medical Informatics ISSN 2191-530X ISSN 2191-5318 (electronic) ISBN 978-981-287-259-3 ,ISBN 978-981-287-260-9 (eBook) DOI 10.1007/978-981-287-260-9. Pp 41-51.

3.Bhattacharya S, Bhattacharjee S, Biswas P K, Das A, Bagchi A ;LCMV Interaction Changes with T192M Mutation in Alpha-Dystroglycan; Computational Intelligence in Medical Informatics (2015), Springer Briefs in Applied Sciences and Technology; Forensic and Medical Bioinformatics, Series editors: Amit Kumar, Hyderabad, India and Allam Appa Rao, Hyderabad, India. Naresh Babu Muppalaneni and Vinit Kumar Gunjan. Editors of Computational Intelligence in Medical Informatics ISSN 2191-530X ISSN 2191-5318 (electronic) ISBN 978-981-287-259-3 ,ISBN 978-981-287-260-9 (eBook) DOI 10.1007/978-981-287-260-9. Pp11-23.

4.Ali A, Bhattacharjee S and Bagchi A; Structural Analyses of the Mode of Binding between AANAT protein with 14-3-3 protein involved in Human melatonin synthesis, published in the book Advances in Intelligent System and Computing. Proceedings of Second International Conference INDIA 2015, Volume 2, Series: Advances in Intelligent Systems and Computing, Vol. 340. Mandal, J.K., Satapathy, S.C., Kumar Sanyal, M., Sarkar,P.P., Mukhopadhyay, A. (Eds.) ISBN 978-81-322-2247-7.

5.Das A, Bhattacharya S, Bhattacharjee S, Dasgupta R, Bagchi A; Computational analyses of the length and compositional variations of the FNBP4 gene across 10 different species: Gene; 10.1016/j.gene.2015.09.087.

6.Bhattacharjee S, Dasgupta R and Bagchi A; The Small Heat-Shock Proteins IbpA and IbpB in E. coli: the Small ones with a Big Role. Current Chemical Biology, Vol. 9, pp 1-13, ISSN: 1872-3136,
DOI: 10.2174/2212796809666151022202506.
University of Kalyani, Nadia, West-Bengal, India.
Bioinformatics Infrastructure Facility
A DBT (Govt. of India) Sponsored Facility.
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